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  • 产品名称: 2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶
  • 产品编号: HQS-140407
  • 上架时间: 2017-02-14
  • CAS: 446859-33-2
  • 浏览次数: 11
  • 市场价:

CAS号: 446859-33-2

M.F: C17H13N5

M.W: 287.318

Description:
IC50 Value: N/A

RepSox can efficiently replace transgenic Sox2 in the absence of VPA and cMyc, as well as in both embryonic and adult fibroblasts, we chose to further characterize E-616452 and named it RepSox, for Replacement of Sox2.
in vitro: Pretreated MEFs with RepSox, applying the chemical for three days, and then removed it at the time of transduction with Oct4, Klf4, and cMyc. In these experiments, no Oct4+GFP+ colonies were formed, suggesting that RepSox does not act on the initial somatic cells to replace Sox2. Consistent with this result, we did not detect a significant increase in the expression of endogenous Sox2or closely related Sox family members upon RepSox treatment [1]. RepSox did increase by 5-fold the expression of L-Myc, a close homolog of cMyc that can functionally replace it in reprogramming.

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