产品分类

全部分类



浏览量:

215

2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶

零售价

0.0

元

市场价

0.0

元

浏览量:

215

产品编号

HQS-140407

01:

446859-33-2

02:

03:

04:

05:

06:

07:

08:

09:

10:

11:

12:

数量

库存:

所属分类

返回列表



产品描述

参数

CAS号: 446859-33-2

M.F: C17H13N5

M.W: 287.318

Description:
IC50 Value: N/A

RepSox can efficiently replace transgenic Sox2 in the absence of VPA and cMyc, as well as in both embryonic and adult fibroblasts, we chose to further characterize E-616452 and named it RepSox, for Replacement of Sox2.
in vitro: Pretreated MEFs with RepSox, applying the chemical for three days, and then removed it at the time of transduction with Oct4, Klf4, and cMyc. In these experiments, no Oct4+GFP+ colonies were formed, suggesting that RepSox does not act on the initial somatic cells to replace Sox2. Consistent with this result, we did not detect a significant increase in the expression of endogenous Sox2or closely related Sox family members upon RepSox treatment [1]. RepSox did increase by 5-fold the expression of L-Myc, a close homolog of cMyc that can functionally replace it in reprogramming.

关键词:

446859-33-2